Centro de Vigilancia y Seguridad de Medicamentos

El trabajo realizado por el centro es el producto de una labor conjunta y coordinada entre todos sus miembros, lo que suele generar la participación de profesionales se secciones y/o laboratorios distintos en un mismo trabajo:

2023:

  • Barcia RE, Keller GA, Azzato F, Diez RA, Sielecki M, Samson Kleine R, Lescano JA, Giunti G. Development and Implementation of a Computerized Medical Decision Support System to Reduce Polypharmacy and Drug-Drug Interactions in Hospitalized Patients. Reviews on Recent Clinical Trials 2023; 18(1):In press. Pubmed / Full Text
  • Di Girolamo Guillermo, Keller GA, Beider L, Gonzalez CD, Gonzalez Bagnes M, González E, Fornari MC, Diez RA. Pharmacokinetic and pharmacodynamic study of 3 products of epoetin alfa as single subcutaneous dose in healthy volunteers. Fundamental & Clinical Pharmacology 2023; (in press). Pubmed / Full Text

2022:

  • Temprano G, Keller GA, Ucedo M, Dokmetjian JC, Cohen MM. Quality Management Systems Underpinning National Public Health Institutes Units and Leverage of Organisational Knowledge Research. Health Education and Public Health 2022; 5(2): 503-507. doi: 10.31488/HEPH.178 Pubmed / Full Text
  • Cannellotto M, Duarte M, Keller GA, Larrea R, Cunto E, Chediack V, Mansur M, Brito DM, García E, Di Salvo HE, Verdini F, Domínguez C, Jorda-Vargas L, Roberti J, Di Girolamo G, Estrada E. Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: a randomised controlled trial. Emerg Med J. 2022 Feb;39(2):88-93. Pubmed / Full Text

2020:

  • Keller GA, Ferreiros-Gago ML, Di-Salvo H, Di Girolamo G. Precision Medicine in the Renin-Angiotensin System: Therapeutic Targets and Biological Variability. Curr Drug Targets 2020;21(15):1625-1637. Pubmed / Full Text

2018:

  • Keller GA, Villa-Etchegoyen MC, Fernandez N, Olivera N, Quiroga P, Diez RA, Di Girolamo G. Dextrophropoxyphene Effects on QTc-Interval Prolongation: Frequency and characteristics in relation to plasma levels. Journal of Opioid Management 2018; 14(5):335-344.. Pubmed / Full Text

2017:

  • Etchegoyen CV, Keller GA, Mrad S, Cheng S, Di Girolamo G. Drug-induced QT Interval Prolongation in the Intensive Care Unit. Curr Clin Pharmacol. 2017;12(4):210-222. Pubmed / Full Text
  • Fernández N, Olivera NM, Keller GA, Diez RA, Di Girolamo G, Quiroga PN. Simultaneous quantitation of meperidine, normeperidine, tramadol, propoxyphene and norpropoxyphene in human plasma using solid-phase extraction and gas chromatography/mass spectrometry: Method validation and application to cardiovascular safety of therapeutic doses. Rapid Commun Mass Spectrom. 2017 Sep 30;31(18):1519-1533. doi: 10.1002/rcm.7933. Erratum in: Rapid Commun Mass Spectrom. 2017;31(23):2056. Pubmed / Full Text
  • Keller GA, Gago MLF, Diez RA, Di Girolamo G. In vivo Phenotyping Methods: Cytochrome P450 Probes with Emphasis on the Cocktail Approach. Curr Pharm Des. 2017;23(14):2035-2049. Pubmed / Full Text
  • Keller GA, Villa Etchegoyen MC, Fernández N, Olivera NM, Quiroga PN, Diez RA, Di Girolamo G. Meperidine-induced QTc-interval prolongation: prevalence, risk factors, and correlation to plasma drug and metabolite concentrations?. Int J Clin Pharmacol Ther. 2017;55(3):275-285. Pubmed / Full Text

2016:

  • Bril F, Castro V, Gomez Centurion I, Espinosa J, Keller GA, Gonzalez CD, Soler C, Lopez Saubidet C, Di Girolamo G, Alvarez PA. Assessing the Burden of Drug Interactions in Kidney Transplant Patients. Curr Drug Saf. 2016;11(2):156-63. Pubmed / Full Text
  • Keller GA, Villa Etchegoyen MC, Fernandez N, Olivera NM, Quiroga PN, Belloso WH, Diez RA, Di Girolamo G. Meperidine Induced QTc-Interval Prolongation: Prevalence, Risk Factors and Correlation to Plasma Drug and Metabolite Concentrations. Curr Drug Saf. 2016; in press. Pubmed / Full Text
  • Keller GA, Villa Etchegoyen MC, Fernandez N, Olivera NM, Quiroga PN, Belloso WH, Diez RA, Di Girolamo G. Tramadol Induced QTc-Interval Prolongation: Prevalence, Clinical Factors and Correlation to Plasma Concentrations. Curr Drug Saf. 2016; in press. Pubmed / Full Text
  • Farias J, Keller GA, Papouchado M, Criscuolo ME, Diez RA, Di Girolamo G. Relative bioavailability between two teriparatide formulations in healthy volunteers. Int J Clin Pharmacol Ther 2016; 54(8):649-56. Pubmed /Full Text
  • Keller GA, Czerniuk P, Bertuola R, Villa Etchegoyen MC, Mendez M, Gimenez MI, Di Girolamo G. Comparative bioavailability of 2 tablet formulations of emtricitabine /tenofovir in healthy, fasting volunteers: a single-dose, randomized-sequence, open-label crossover study. Int J Clin Pharmacol Ther 2016; 54(1); in press. Pubmed / Full Text
  • Keller GA, Alvarez PA, Ponte ML, Belloso WH, Bagnes C, Gonzalez CD, Villa Etchegoyen MC, Diez RA, Di Girolamo G. Drug-induced QTc interval prolongation: A multicenter study to detect drugs and clinical factors involved in every day practice. Curr Drug Saf. 2016;11:86-98. Pubmed / Full Text

2015:

  • Oliveri B, Mastaglia SR, Brito GM, Seijo M, Keller GA, Somoza J, Diez RA, Di Girolamo G. Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach. Eur J Clin Nutr. 2015;69(6):697-702. Pubmed / Full Text

2014:

  • Keller GA, Fabian L, Gomez M, Gonzalez CD, Diez RA, Di Girolamo G. Age-Distribution and genotype / phenotype correlation for N-acetyltransferase in Argentine children under isoniazid treatment. Int J Clin Pharmacol Ther 2014; 52(4): 292-302. Pubmed / Full Text

2013:

  • Alvarez PA, Bril F, Castro V, Meiville I, Gonzalez CD, Gomez Centurion I, Parejas G, Soler Riera C, Lopez Saubidet C, Di Girolamo G, Keller GA. Adverse Drug Reactions as a Reason for Admission to an Internal Medicine Ward in Argentina. Int J Risk Saf Med 2013; 25(3):185-92. Pubmed / Full Text

2012:

  • Alvarez PA, Egozcue J, Sleiman J, Moretti L, Di Girolamo G, Keller GA. Severe neutropenia in a renal transplant patient suggesting an interaction between mycophenolate and fenofibrate. Curr Drug Saf 2012;7(1):24-9. Pubmed / Full Text

2011:

  • Keller GA, Di Girolamo G, Alvarez PA. Pharmacovigilance and the cardiovascular system: two sides to every story. Curr Drug Saf 2011;6(4):224-9. Pubmed / Full Text
  • Keller GA, Czerniuk P, Bertuola R, de Mena F, Simoni MV, Assefi AR, Di Girolamo G. Relative bioavailability of a 5 mg mosapride/10 mg rabeprazole fixed dose combination tablet versus separate single tablets in healthy volunteers: a single-dose randomized open-label crossover study. Curr Med Res Opin 2011;27(11):2203-11. Pubmed / Full Text
  • Keller GA, Czerniuk P, Bertuola R, Spatz JG, Assefi AR, Di Girolamo G. Comparative bioavailability of 2 tablet formulations of levodopa/benserazide in healthy, fasting volunteers: a single-dose, randomized-sequence, open-label crossover study. Clin Ther 2011;33(4):500-10. Pubmed / Full Text
  • Altman R, Scazziota AS, Pons S, Herrera L, Keller GA, Assefi AR, Di Girolamo G. Effects of enoxaparin preparations on thrombin generation and their correlation with their anti-FXa activity. Curr Med Res Opin. 2011 Jan;27(1):1-9. Pubmed / Full Text

2010:

  • Di Girolamo G, Czerniuk P, Bertuola R, Keller GA. Bioequivalence of Two Tablet Formulations of Clopidogrel in Healthy Argentinian Volunteers: A Single-Dose, Randomized-Sequence, Open-Label Crossover Study. Clinical Therapeutics 2010; 32(1):161-170. Pubmed / Full Text
  • Di Girolamo G. Drug-induced at interval prolongation: clinical, safety and regulatory updaes. Curr Drug Saf. 2010;5(1):41-3. Pubmed
  • Ponte ML, Keller GA, Di Girolamo G. Mechanisms of drug induced QT interval prolongation. Curr Drug Saf. 2010;5(1):44-53. Pubmed / Full Text
  • Giorgi MA, Bolaños R, Gonzalez CD, Di Girolamo G. QT interval prolongation: preclinical and clinical testing arrhythmogenesis in drugs and regulatory implications. Curr Drug Saf. 2010;5(1):54-7. Pubmed
  • Keller GA, Di Girolamo G. Antihistamines: past answers and present questions. Curr Drug Saf. 2010;5(1):58-64. Pubmed / Full Text
  • Taira CA, Opezzo JA, Mayer MA, Höcht C. Cardiovascular drugs inducing QT prolongation: facts and evidence. Curr Drug Saf. 2010;5(1):65-72. Pubmed
  • Keller GA, Di Girolamo G. Prokinetic agents and QT prolongation: a familiar scene with new actors. Curr Drug Saf. 2010;5(1):73-8. Pubmed / Full Text
  • Gonzalez CD, de Sereday M, Sinay I, Santoro S. Endocrine therapies and QTc prolongation. Curr Drug Saf. 2010;5(1):79-84. Pubmed
  • Bril F, Gonzalez CD, Di Girolamo G. Antimicrobial agents-associated with QT interval prolongation. Curr Drug Saf. 2010;5(1):85-92. Pubmed
  • Bagnes C, Panchuk PN, Recondo G. Antineoplastic chemotherapy induced QTc prolongation. Curr Drug Saf. 2010;5(1):93-6. Pubmed
  • Alvarez PA, Pahissa J. QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf. 2010;5(1):97-104. Pubmed
  • Keller GA, Ponte ML, Di Girolamo G. Other drugs acting on nervous system associated with QT-interval prolongation. Curr Drug Saf. 2010;5(1):105-11. Pubmed / Full Text

2008:

  • Di Girolamo G, Keller GA, de los Santos AR, Schere D, Gonzalez CD. Bioequivalence of Two Levothyroxine Tablet Formulations Without and With Mathematical Adjustment for Basal Thyroxine Levels in Healthy Argentinian Volunteers: A Single-Dose, Randomized, Open-Label, Crossover Study. Clinical Therapeutics 2008;30(11):2015-23. Pubmed / Full Text
  • Di Girolamo G, Kauffman MA, Gonzalez E, Papouchado M, Ramirez A, Keller G, Carbonetto C, Dabsys S, Vidal A, Sterin-Prync A, Diez RA. Bioequivalence of two subcutaneous pharmaceutical products of interferon beta 1a. Arzneimittel-Forschung 2008;58(4) 193-198. Pubmed / Full Text

2007:

  • Di Girolamo G, Opezzo JAW, Lopez MI, Schere F, Keller G, Gonzalez CD, de los Santos MC. Relative bioavailability of new formulation of paracetamol effervescent powder containing sodium bicarbonate versus paracetamol tablets: a comparative pharmacokinetic study in fed subjects. Expert Opin Pharmacother 2007;8(15):1-9. Pubmed / Full Text