Cátedra II de Fisiología

 6 años ago By admin

 

LABORATORIO DE ENDOCRINOLOGIA

 

El Laboratorio de Endocrinologia  está abocado al estudio de los efectos que provocan los Disruptores endocrinos sobre distintas funciones endocrinas, en especial las sexuales y tiroideas; así como los cambios neuroendocrinas-conductuales y sus mecanismos que provocan estos disruptores endocrinos.

Por otra parte estudiamos las alteraciones cardiovasculares y renales provocadas por un estado de hiperuricemia y la diabetes.

 

Líneas de Investigación:

 

1. Estudios en animales:

 

“Acción de los Disruptores endocrinos sobre la conducta ansiogénica y sexual y sus mecanismos de regulación en ratas.”

 

“Consumo de agua de napas y su relación con el hipotiroidismo endémico humano. Posible acción disruptora endocrina. Relación con un modelo experimental en Xenopus Laevis.”

 

“Efecto de los Disruptores Endocrinos sobre el desarrollo puberal, la maduración sexual”.

 

“Rol de la hiperuricemia y el síndrome metabólico sobre el sistema cardiovascular, renal y metabólico en ratas. Su relación con el estado gonadal”.

2. Estudios en Pacientes:

“Marcadores tisulares de malignidad, para el seguimiento pre quirúrgico del microcarcinoma tiroideo”.

“Rol de la hiperuricemia y la diabetes sobre el sistema cardiovascular, renal y metabólico”.

 

 

 

 

Integrantes:

 

Director:

 

  • Prof. Dr. Osvaldo J. Ponzo. Profesor Titular de Fisiología y Biofísica. Dr. en Ciencias Fisiológicas, Universidad de Buenos Aires. Médico especialista en Endocrinología y Metabolismo. Dirección desde año 2011.

 

 

 Investigadores:

  • Dra. María Fernanda Modarelli. Jefa de trabajos Prácticos de Fisiología y Biofísica. Dra. en Ciencias Fisiológicas. Medica Especialista en Inmunología.
  • Médico Rodrigo M. Bilbao. Jefe de trabajos Prácticos de Fisiología y Biofísica. Médico especialista en Psiquiatra. Tesista de Doctorado UBA.
  • Médica María Jimena Soutelo. Jefa de trabajos Prácticos de Fisiología y Biofísica. Médica especialista en Endocrinología y Metabolismo.
  • Médica Yanina Alejandra Samaniego. Ayudante de Primera de Fisiología y Biofísica Medica Especialista en Infectología. Ex Beca estímulo UBA.
  • Médico Claudio Berardi. Jefe de trabajos Prácticos de Fisiología y Biofísica Médico especialista en Clínica Médica y medicina interna. Dr. en Ciencias de la salud Fundación Barcelo. Magister en Educación Superior. Universidad. Nacional de La Matanza.

 

Técnicos Profesionales:

  • Verónica Zucarella. Licenciada en Genética.
  • Ricardo Chung. Licenciado en Ciencias Ambientales.

 

Técnicos:

  • Pablo Cepero. Encargado de Criadero y  manejo de animales experimentales.

 

 Colaboradores:

  • Dr. Gabriel Casas. Médico especialista de Patología. Jefe de Servicio de Patología. Hospital Alemán.

Pasantes:

  • Felipe Merovich. Ayudante de segunda, UA2.
  • Franco Pachetti. Ayudante de segunda, UA2.
  • Renata Altuna. Ayudante de segunda, UA2.
  • Joaquín Manfre. Ayudante de segunda, UA2.
  • José Ignacio Serralunga. Ayudante de segunda, UA2.

 

Ex Directores:

  • Prof. Dr. Pablo Scacchi. Profesor Consulto de Fisiología, UBA.  Medico. Investigador Independiente del CONICET. Años 2003 a 2010.
  • Prof. Dr. Jaime A. Moguilevsky. Profesor Emérito de Fisiología, UBA.  Medico. Investigador Superior del CONICET. Años 1986 a 2002.

Ex integrantes:

  • Dra. Roxana Reynoso. Bioquímica, Especialista en Endocrinología. Dra. en Ciencias Fisiológicas, Universidad de Buenos Aires.
  • Dr. Pablo Scacchi Bernasconi. Medico. Dr. en Ciencias Fisiológicas. Universidad Católica Argentina.
  • Licencianda en Biología Laura Deguiz. Tesis de Licenciatura y Beca estímulo UBA.
  • Dra. Silvia Carbone. Bioquímica. Técnica Profesional del CONICET.
  • Medica. María Elena Carou. Beca estímulo UBA.
  • Doctora Georgina Paula Ossani. Medica especialista en Patología. Investigador adjunto CONICET.
  • Medico Ezequiel Becher. Beca estímulo UBA.
  • Bioquímica María Ángeles Cacciamano. Pasantía de rotación Disruptores Endocrinos de la residencia de Bioquímica Endocrina, Servicio de Endocrinología, Hospital de Niños de la Santísima Trinidad, Córdoba).
  • Maximilano Ink                         Pasante estudiante medicina.  Desde 3/2019 hasta 3/2020.
  • Debora Correa Loureiro          Pasante estudiante medicina. Desde 3/2019 hasta 4/2023.
  • Agustina Cotic                         Pasante estudiante medicina. Desde 3/2019 hasta 3/2021.
  • Martina Izurieta                       Pasante estudiante medicina. Desde 3/2019 hasta 3/2021.
  • Yamila Villaverde                    Pasante estudiante  medicina. Desde 3/2014 hasta 3/2015.
  • Florencia Sarratea                   Pasante estudiante medicina. Desde 5/2011 hasta 8/2012.
  • Camila Benito                          Pasante estudiante medicina Desde 7/2008 hasta 3/2009.
  • Ferrari Natalia Giselle             Pasante estudiante medicina. Desde 3/2008 hasta 3/2009.
  • Garcia Arabéhéty Julia                        Pasante estudiante medicina.             Desde 8/2007 hasta 3/2010.
  • Florencia Biasoli                      Pasante estudiante medicina. Desde 3/2006 hasta 3/2007.
  • Evangelina Petrocino              Pasante estudiante medicina Desde 3/2005 hasta 3/2007.
  • Gustavo Pawluk:                     Pasante estudiante medicina. Desde 3/2003 hasta 3/2005
  • Romina Cardozo:                    Pasante estudiante medicina. Desde 3/2003 hasta 6/2007.
  • Maria Elena Carou:                 Pasante estudiante medicina. Desde 3/2003 hasta 3/2010.
  • Ximena Lopez Mujica:             Pasante estudiante medicina. Desde 3/2002 hasta 3/2003.

 

Publicaciones destacadas

 

2022: Water Contamination by Nitrates and its Thyroid Disruptive Action. Bioassay on Xenopus Laevis 

https://drive.google.com/file/d/1BawSJRlaJTDtHFWXWwUp9mZMJFiKkSIg/view?usp=sharing

2020:Renal Damage During Continuous Versus Intermittent Treatment with Lithium 

https://drive.google.com/file/d/11K5Q-_fmPWO5i9dEFVny4SCshSEccN3Y/view?usp=sharing

2019: https://drive.google.com/file/d/11K5Q-_fmPWO5i9dEFVny4SCshSEccN3Y/view?usp=sharing

2019:RELACIÓN DEL HIPOTIROIDISMO SUBCLÍNICO Y BOCIO CON EL ORIGEN DEL
AGUA CONSUMIDA POR UNA POBLACIÓN DEL CONURBANO BONAERENSE

 https://drive.google.com/file/d/1gVC47YkC7kPhxHtlR-16QOHCI7QHnBlk/view?usp=sharing

2019:Effect of di(2-ethylhexyl) phthalate on the neuroendocrine regulation of reproduction in adult male rats
and its relationship to anxiogenic behavior: Participation of GABAergic system

 https://drive.google.com/file/d/1kjj5gwgHPLxD03qlhWlqmz8dWTkSH1f7/view?usp=sharing

2019:Cardiovascular Changes in Normo and Hypogonadal Rats Treated with a High-Fructose Diet and Induced
Hyperuricemia Condition 

https://drive.google.com/file/d/1R-nuC32jxr1jgOFIb6ZU8jjGMUSUq8P6/view?usp=sharing

2018:Disruptores endocrinos: Guía dereconocimiento, acciones y recomendaciones para el manejo médico 

https://drive.google.com/file/d/1GCtbYhbHE4D8I-itgu2cNQZFxfObp0TW/view?usp=sharing

2018:Cardiometabolic Changes in Different Gonadal Female States Caused by Mild Hyperuricemia and Exposure to a High-Fructose Diet 

https://drive.google.com/file/d/1OATO3YgSVHXtE-mukqszkgjxgui-XhOF/view?usp=sharing

2017:Influence of Normo- and Hypogonadal Condition, Hyperuricemia, and High-Fructose Diet on Renal Changes in
Male Rats 

https://drive.google.com/file/d/115Rb-j2a5jqnCz1iWeqZgME-2I28rK2i/view?usp=sharing

2015:Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats Effects on early folliculogenesis 

https://drive.google.com/file/d/1YWmaSQ3FC62BcDP2Rvpl1bUgAqApKR5r/view?usp=sharing

2013: Low dose of bisphenol A impairs the reproductive axis of prepuberal male rats

https://drive.google.com/file/d/1d5YpzlrFJs0Hz09nE8-B4SNXBzQRGMm4/view?usp=sharing

2013: Leptin inhibits the reproductive axis in adult male Syrian hamsters exposed to long and short
photoperiod

https://drive.google.com/file/d/1VGPNzWKqW6ZY-9OjHVxjx27C7E6URKsS/view?usp=sharing

2013:Evidence of reproductive disruption associated with neuroendocrine changes induced by UV–B filters, phtalates and nonylphenol during sexual maturation in rats of both gender

 https://drive.google.com/file/d/1Z6loSR3kFvVSFK6Tp4Vfg8U-TOcb_SEw/view?usp=sharing

2013: Antiandrogenic effect of perinatal exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate increases anxiety-like behavior in male rats during sexual maturation

https://drive.google.com/file/d/1W8Hvd34vRFk_DNDl0FzzP1D6ctajUtq3/view?usp=sharing

2012: Different effects by sex on hypothalamic–pituitary axis of prepubertal offspring rats produced by in utero and lactational exposure to di-(2-ethylhexyl) phthalate(DEHP)

https://drive.google.com/file/d/1w0uCfRlbD4THlPSK1J3GyLrfb1U_15Xn/view?usp=sharing

2011:Probable gamma-aminobutyric acid involvement in bisphenol A effect at the hypothalamic level
in adult male rats 

https://drive.google.com/file/d/19Gc4NQ0DAcgqSp3Ap3M7h7BUMIVKphDM/view?usp=sharing

2010:Reproductive axis response to repeated lipopolysaccharide administration in peripubertal female rats

 https://drive.google.com/file/d/1AgR-GYRh6a1DoXz6t6F6-vJ4grBzMgqg/view?usp=sharing

2010:In vitro Effect of Octyl-Methoxycinnamate(OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adults Rats

  https://drive.google.com/file/d/1VtKFxvGByVXRnQ1N_Vx5Yz84FTd9bjSF/view?usp=sharing

2010:Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male rats

 https://drive.google.com/file/d/1qY1KPOSQTU0xkKU7g7vGVx9sNr2NUSeB/view?usp=sharing

2010:Evidence to suggest glutamic acid involvement in Bisphenol A effect at the hypothalamic level in prepubertal malerats

 https://drive.google.com/file/d/1ZO-yVJKzOThQF22sGEIcIFHBDHigtqYq/view?usp=sharing

2010: Efectos de la administración de bisfenol A en etapas clavede la maduración sexual

https://drive.google.com/file/d/1PsClnasyfwROyCahyRu4y1ZnoAMh5Vjh/view?usp=sharing

2009:Impact of the UV-B filter 4-(Methylbenzylidene)-camphor (4-MBC) during prenatal development in the neuroendocrine regulation of gonadal axis in male and female adult rats 

https://drive.google.com/file/d/11wJD18MZGM6argLKqC1Frxfm5RFSl_OR/view?usp=sharing

2009: Impact of 4-Methylbenzylidene-camphor (4-MBC) during Embryonic and Fetal Development in the
Neuroendocrine Regulation of Testicular Axis in Prepubertal and Peripubertal Male Rats

https://drive.google.com/file/d/1ET9QNgImzhlWtiezo6w6pGRPEOjWf0L2/view?usp=sharing

2008:Efecto de la exposicion transgeneracional  al disruptor endocrino di-2-etilhexil-fatalato, sobre la secrecion de gonadotrofinas en ratas peripuberes

https://drive.google.com/file/d/10QPsaiHjAoKcZ44HoRRpnaqzccGVTUDN/view?usp=sharing

2008:Low dose 4-MBC effect on neuroendocrine regulation of reproductive axis in adult male rats

 https://drive.google.com/file/d/1mm5nVdr4ek0WjZLtbVS9zV2HVTXPX-zH/view?usp=sharing

2008:Effect of Bacterial Lipopolysaccharide on the Reproductive Axis of Prepubertal and
Peripubertal Female Rats 

https://drive.google.com/file/d/1hN5QVxQTimTQwupL3DldNu1qAGIlcjhu/view?usp=sharing

2008:Efecto de la exposición transgeneracional al disruptor endócrino di-2-etilhexil-fatalato, sobre la secreción de gonadotrofinas en ratas peripúberes

 https://drive.google.com/file/d/1u4fQ97qQxAbLJznN2X82u3QTUmosDrfl/view?usp=sharing

2007:Experimental and Clinical Endocrinology and Diabetes

 https://drive.google.com/file/d/1kVw8OqxQFY0pr0NuFq7Me4WhXdQhH98j/view?usp=sharing

2006:Endogenous hypertriglyceridemia intensifies the course of cerulein-induced pancreatitis in rat. Relation with change in the VLDL composition

 https://drive.google.com/file/d/11wL1CBcc9Q_TlYRmgbqxb60eA6SxQEre/view?usp=sharing

2005:Leptin stimulates the reproductive male axis in rats during sexual maturation by acting on hypothalamic excitatory amino acids

 https://drive.google.com/file/d/1MxwZi13TBM4vjIXL5hqK_oCStiiK6k3f/view?usp=sharing

2005:Leptin stimulates LH secretion in peripubertal male rats through NMDA receptors

 https://drive.google.com/file/d/1zy2wYIAAeDzqtaYuddxf760tL58j-pVL/view?usp=sharing

2004:Hypothalamic nitric oxidesynthase activity during sexual maturation in famele rats-

 https://docs.google.com/document/d/1lxDx1WWFGT_rNMcDOsCAWX1hIWN01RaL/edit?usp=sharing&ouid=100277305496150511731&rtpof=true&sd=true

2004:Effect of Leptin on LH Levels and Hypothalamic Release of GnRH. Its Relationship with the Hypothalamic
Neurotransmitter Amino Acids System in Adult Male Rats

 https://drive.google.com/file/d/1s-46Pf5LESt9fYYH3Ji3h0BtvFmPhN6H/view?usp=sharing

2003:EFFECT OF LEPTIN ON HYPOTHALAMIC RELEASE OF GnRH and neurotrasmitter amino acids during sexual maturation in famele rats

 https://docs.google.com/document/d/118XLlpweqPgrDsbdUC8R2DN4zULWZsZb/edit?usp=sharing&ouid=100277305496150511731&rtpof=true&sd=true

2003:Effects of gabaergic and serotoninergic systems on hypothalamic content of catecholamines during sexual
development in female rats

https://drive.google.com/file/d/1n4fXpB4zc7VtyiCdW_0QZJyXMjwdOzPb/view?usp=sharing

2002:Ontogenic modifications in the effect of the GABAergic system on the hypothalamic excitatory amino acids: its relationship with GABAergic control of gonadotrophin secretion during sexual maturation in female rats

 https://drive.google.com/file/d/19ZKX6-z93OTcoNA1_zHOQjfpNexPZhvP/view?usp=sharing

2002:Changes in the Effect of Testosterone on Hypothalamic Nitric Oxide Synthetasa During Sexual Maturation.Its Relationship with GnRH Release

 https://drive.google.com/file/d/1pUdrOpunwLF--Qj8KRONjlKBh3i6cLMb/view?usp=sharing

2001:Changes in the Sensitivity of Gonadotrophin Axis to Leptin During Sexual Maturation in Female Rats

 https://drive.google.com/file/d/1Y5ESLwGJyPkMyRgj5jPeQxXOfdhr-Fhi/view?usp=sharing

2000:  Interrelationships of GABAergic, serotoninergic and excitatory aminoacid systems in its regulatory effect on prolactin secretion in prepubertal rats

https://drive.google.com/file/d/1KlH089nbciyPJyeQzV1qYtYPaRHeOa3Q/view?usp=sharing

2000: IL-1 inhibits NMDA stimulated GnRH secretion_ associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters

https://drive.google.com/file/d/1WdM9pl98_GYVEDn6S_EqZ_7D3Xm4k-_D/view?usp=sharing

2000:IL-1 inhibits NMDA stimulated GnRH secretion_ associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters

 https://drive.google.com/file/d/1W4IO3yv1LtwP2eCah4x5eWzl34ku_BTp/view?usp=sharing

2000:Effect of  aproteic diet and fasting on insulin, pancreatic noradrenaline and luteinizing hormone. Change after 24 hours refeeding

 https://drive.google.com/file/d/13sq97mcubOq5xldT7UWAObWn59CdJNIp/view?usp=sharing

2000: Aproteic diet decreases hypothalamic catecholamine turnover in adult male rats

https://drive.google.com/file/d/10lsFpPz-TPR_2d6YNUY4PmWy7GBN1Oea/view?usp=sharing

2000:  Age related differences in the effects of bacterial endotoxin LPS upon the release of LHRH gonadotropins and hypothalamic inhibitory amino acid naurotransmitters

https://drive.google.com/file/d/1W_UNvDbdcTBGYDMi4-_arrATxvy7pBVM/view?usp=sharing

1999: GABAergic activation inhibits the hypothalamic pituitary ovaric axis and sexual development in the immature female rat

https://drive.google.com/file/d/11io2qfPS-BqWKeGJlqDGvla1kKsMc_Eq/view?usp=sharing

1999: Effects of the GABA-A receptor agonist and antagonist on the in vitro release of hypothalamic catecholamines

https://drive.google.com/file/d/1gl9Xjkp3WQagqCe_B2sl-9rLDiVjwmC0/view?usp=sharing

1999: Effects of aproteic diet on hypothalamic pituitary gonadal regulation in the male rat

 https://drive.google.com/file/d/15WHvnCPfW_cHS0hnWkkImZX3l50_nX8I/view?usp=sharing

1999: Effect of aproteic diet on hypothalamic-pituitary-gonadal regulation in the male rat

https://drive.google.com/file/d/1pTTYAFXxAPPQCFeB_OPeTN8_MGQed5PI/view?usp=sharing

1999:Effect of an aproteic diet on gonadotropin release response to GnRH and estrogen-progesterone in rats

 https://drive.google.com/file/d/1LVq715jZcZVjS6ynFP6hDFGg71tMjMdQ/view?usp=sharing

1999: Effect of an aproteic diet on gonadotropin release response to GnRH and estrogen progesterone in rats

https://drive.google.com/file/d/1JdFxlYo_F8oty3lJGgRmvRggMQJnRZkx/view?usp=sharing

1999:Arrest of pulsatile LH secretion during insulin-induced hypoglycemia_ Improvement by intrahypothalamic perfusion with glucose

 https://drive.google.com/file/d/13-Kf5XFg2mgwuWiNIp9Z6eJD0ChskZ3R/view?usp=sharing

1998: Interleukin-1 stimulates hypothalamic inhibitory amino acid neurotransmitter release

 https://drive.google.com/file/d/1C2AvkmXGfDrQOvPymbadkQfZo1PtI9kl/view?usp=sharing

1998:Effects of fasting and aproteic diet on prolactin regulation in the rat

 https://drive.google.com/file/d/1AC5SGWOXTB5zhYIiLs-pQSd_ft4Fe4oD/view?usp=sharing

1998:  Effect of fasting and aproteic diet on prolactin regulation in the rathttps://drive.google.com/file/d/17gzHvLu9LoMAystx3-9wUwpn1sdMUZb9/view?usp=sharing

1998: Effect of bacterial endotoxin on in vivo pulsatile gonadotropin secretion in adult male rats

 https://drive.google.com/file/d/1sfDAlUaXFKzqECpSePeRR-vyLbu5HnJZ/view?usp=sharing

1998:Detection of prolactin receptor gene expression in the sheep pituitary gland and visualization of the specific translation of the signal in gonadotrophs

 https://drive.google.com/file/d/1tamBZR8jMigoZzESWQxfKXHaAScrm7HF/view?usp=sharing

1998: Changes in mediobasal hypothalamic dopamine and GABA release

https://drive.google.com/file/d/1xe1vwibNwASCplrIIcIKEpR0sJGp5T9J/view?usp=sharing

1997: La dieta hiperlipidica cronica intensifica la pancreatitis aguda inducida por ceruleina en la rata

https://drive.google.com/file/d/1w0T7r9fLD-VUlIUaltYZR3lLiFPr-Pbp/view?usp=sharing

1997: Involvment of GABA in the postnatal function of the GnRH pulse generator as determined

https://drive.google.com/file/d/1fq4LqJ3sMYLlmzrzAgAw3hGzMAK1-Sa5/view?usp=sharing

1996:The GABAergic control of GnRH secretion in male rats during sexual maturation involves effects on hypothalamic excitatory and inhibitory amino acid systems

 https://drive.google.com/file/d/1uV-2OX3v3vDG1MmxWnyb7OGe7aEiA9Cx/view?usp=sharing

1996:  Evidence to Suggest that gonadotropin releasing hormone inhibits its own secretion by affecting hypothalamic amino acid neurotransmitter release

https://drive.google.com/file/d/1Rz7BHWfXH-vY87fDb09oaHYC6vKZNdTo/view?usp=sharing

1996:Effects of endotoxin on in vitro release of LHRH and amino acid neurotransmitters by preoptic mediobasal hypothalamic fragments

 https://drive.google.com/file/d/1gub1XWY_6_CyI4F8INU0znvO6_Nv-Qpk/view?usp=sharing

1996: Effects of aging on NMDA induced GnRH and LH release in female rats

https://drive.google.com/file/d/1-pgrVySRg1nScW6Qmzv6mMWSq63z9hDp/view?usp=sharing

1995: Repeated intracerebroventricular administration of taurine lowers LH levels and postpones vaginal opening in prepuberal female rats

https://drive.google.com/file/d/1smfiXUKRsQ8TQoGBcMim54xqluXz7pbv/view?usp=sharing

1995: Peripheral autonomic regulation of gonadotropin secretion in puberal rats

https://drive.google.com/file/d/1wWqOMCsjBSNJQj9QASQqJjG7gHqPpmG_/view?usp=sharing

1995:Hypothalamic excitatory amino acid system during sexual maturation in female rats

https://drive.google.com/file/d/1S7tRN3uO5d0XKLr-zYq3jYPzWoI7zkMm/view?usp=sharing

1995:Effect of ovarian hormones on the hypothalamic excitatory amino acids system during sexual maturation in female rats

 https://drive.google.com/file/d/1DGvnH5sOBcslMph8RvhvNb9eXEKObN9I/view?usp=sharing

1995: Changes in the hypothalamic interaction between norepinephrine and PGE2 during sexual maturation in female rats

https://drive.google.com/file/d/1n3hbuLxDoXnS8T4sqZIjwEh9RMdq5yJI/view?usp=sharing

1994: Sexual differences in the effect of the GABAergic system on LH secretion and in the hypothalamic ontogenesis of GABAa receptor in prepuberal rats

https://drive.google.com/file/d/1EZeX9-wx93QXHObOTYYwsYGd9gFczlaq/view?usp=sharing

1994: Mediobasal hypothalamic perfusion with serotonin inhibits steroid-stimulated LH secretion

https://drive.google.com/file/d/1l0gfkK--OsT930ZDUsf1OGWLm2XWnfaV/view?usp=sharing

1994: Effects of taurine on basal and stimulated LH and LHRH secretion in overiectomized rats

https://drive.google.com/file/d/1eLrYcF0nSzbjaZRum6PevZbNetEOmU0I/view?usp=sharing

1993: Effect of serotoninergic system on the hypothalamic GABAergic activity during sexual maturation in female rats

 https://drive.google.com/file/d/1bs2aJIIcHw8uy1JYmgxJ-JQHkcvSGr6S/view?usp=sharing

1993: Amino Acid levels in the hypothalamus and response to NMDA and_or Disocilpine administration during sexual maturation in female rats

https://drive.google.com/file/d/1HFpCUCb7eKuZJTxWrsmzYuGa_Vgu058p/view?usp=sharing

1992: GABAergic influence on the development of the sexually dimorphic nucleus of male and female rats

https://drive.google.com/file/d/1SW41ObY_4s8xp5V3BX9W8_cF0fmevuTM/view?usp=sharing

1992:  Effects of preoptic anterior hypothalamic perfussion with serotonin upon steroid stimulated LH secretion

https://drive.google.com/file/d/12TbayEn5x74VWzyZB6JzA11pLjpTnhza/view?usp=sharing

1992:Effects of ovarian steroids on the gonadotropin response to NMDA andon hypothalamic excitatory amino acid levels during sexual maturation in female rats

 https://drive.google.com/file/d/1bOLI2Zor3wGKdrTlg8NQTu1RJ3qKfiJz/view?usp=sharing

1992:  Effect of insulin on LHRH release by perifused hypothalamic fragmentshttps://drive.google.com/file/d/1s9KjQLMf1WnegmsHwz-_oanKr6OF_ODA/view?usp=sharing

1992:Changes in the effect of GABA on prolactin secretion during sexual maturation in female rats

 https://drive.google.com/file/d/1K_MmpVJPpsYlQ33iMrsxnr1TzFd2fe1o/view?usp=sharing

1991:Sexual maturation modifies the GABAergic control of gonadotropin secretion in female rats

 https://drive.google.com/file/d/10TkkQmuu6wN6ob5TqgG8BDdD-Reltfvi/view?usp=sharing

1991: Differences in the effect of ovarian hormones on hypothalamic GABAergic activity and on LH release during sexual maturation in female rats

https://drive.google.com/file/d/1YmT-PVJjgydF_OzujBih0rPF50kyGF7D/view?usp=sharing

1990: Sexual maturation modifies the catecholaminergic control of gonadotrophin secretion and the effect of ovarian hormones on hypothalamic neurotransmitters in female rats

https://drive.google.com/file/d/1BChrmZBU_nBqim8CstNC6yfyuzldjBZI/view?usp=sharing

1990:Modulatory Effect of of testosterone on the serotnoninergic control of prolactin secretion in prepuberal rats

https://drive.google.com/file/d/1k3r_g-ySYYD15kw92bhKvC_rtaBPzbUL/view?usp=sharing

1989: Estrous cycle delay and inhibition of gonadotropin and prolactin release during sympathetic nerve degeneration after superior cervical ganglionectomy of rats

https://drive.google.com/file/d/10paVfctVVhhm6R6HmrTJfX9oBu_fq-qA/view?usp=sharing

1989: Effects of H1 and H2 histamine receptor antagonists on positive feed-back effect of estrogen on LH in prepuberal female rats

 https://drive.google.com/file/d/1D4mih3HLvHPsxJmPdZU2jcT2UtVmCsIF/view?usp=sharing

1989:Effect of Serotoninergic system on FSH secretion in male and female rats

 https://drive.google.com/file/d/1i64ZcE0WA-wzE1ssuR5PV2_eT0ysL5iN/view?usp=sharing

1987:Abnormal GH response to GHRF in ataxic patients with spinocerebellar degeneration

 https://drive.google.com/file/d/1iLfNzgZutGa8SOh5xqFrsiVmKIsG0UJV/view?usp=sharing

1986:  Role of Neurotransmitters in the onset of puberty_ Effects on LH secretionhttps://drive.google.com/file/d/1ChM5RwJUgXpX887UK-qooOZQ7JN1Kw3W/view?usp=sharing

1985: Sexual differences in the effect of serotonin opn LH secretion in rats

 https://drive.google.com/file/d/1yFBr398GGZjrWz3rt3QWZnlPNv8S94zQ/view?usp=sharing

1982: Pinealectomy advances the time of development of steroid feedback on luteinizing hormone release in immature female rats

https://drive.google.com/file/d/1nNdVV1mQcYd9_K48Z4Lk4MTtTy9nPzE7/view?usp=sharing

1981:Sexual differences in the development of estrogenic stimulatory mechanismo on prolactin secretion

 https://drive.google.com/file/d/1pAvyen9M1oEfb3oByp0H74NF3ppoC-Y7/view?usp=sharing

1981: Hyperprolactinemia does not affect the development of the stimulatory mechanism of oestrogen progesterone on LH secretion

https://drive.google.com/file/d/1N6TZP9z7u3wPm4JKbDdQ4mVhy5CQjiyI/view?usp=sharing

1980:Neuroendocrine control of ovulation; physiopatological aspects

 https://drive.google.com/file/d/19zTnv39bSCAJNqDps1mhPX1KEYxS03YK/view?usp=sharing

1979:  Failure of melatonin to increase serum prolactin levels in ovariectomized rats subjected to superior cervical gangliectomy or pinealectomy

https://drive.google.com/file/d/1yZQKiKYq-0rWIhbZnBPWpjdlFgOpPfS5/view?usp=sharing

1979:Effect of castration on serum gonadotropin levels in androgenized male and female rats

 https://drive.google.com/file/d/11Fwi1ggQx_84Cjk6PfR_u_fUOAVWJy5i/view?usp=sharing

1978:The effect of oral contraceptives on the gonadotropin response to LHRH

 https://drive.google.com/file/d/11pChO1_G7QLvsMJiv8ckFP9wE8JpUgVG/view?usp=sharing

1978:  L-DOPA y PRL plasmatica en el cancer y displasia mamarios

https://drive.google.com/file/d/19okeKD1x1icvoTlH4JIQJzfLQvH7vUA3/view?usp=sharing

1971:  RNA and protein content in different hypothalamic areas_ Influence of castration

https://drive.google.com/file/d/1JwJ1VKYDnHJJzKjEVolVHAiloMSQczol/view?usp=sharing

1971: Effects of gonadotropins on the oxidative metabolism of hypothalamus

https://drive.google.com/file/d/1qr7S-8wUCzprMs-3Q1BkyMnQJHucLnpo/view?usp=sharing

1970:  Metabolic sensitivity of different hypothalamic areas to LH, FSH, and Testosterone

https://drive.google.com/file/d/11pHaCtKkvjcOvuqVC1v_rJBS3mPhb0bj/view?usp=sharing

1968:  Oxidative and glycolitic metabolism of different hypothalamic areas in diabetic rat

https://drive.google.com/file/d/1z_touN4iSr7yfHbiRnGA6z8X4yGeEIdD/view?usp=sharing

1968: Intrasplenic ovarian implants, studies in androgenized rats

 https://drive.google.com/file/d/1N4DHX_506B9FwwoKwoebDbdQau30lsoT/view?usp=sharing

1961: The effect of cholesterol feeding and of sex hormones on srterial oxygen uptake in chickens

https://drive.google.com/file/d/1SLBXc1Rfm4v7g8XA_aB2t7hZOKj9EGZo/view?usp=sharing

1961:  Testicular action and structural relationships of compounds with antiatherogenic activity

https://drive.google.com/file/d/1F6JK6qtWODc41w8-qdWawN85Q8BI-jVy/view?usp=sharing

1961:Influencia de las gonadas en la regulacion del metabolismo arterial

 https://drive.google.com/file/d/1z4ugJQXtrNcaVAfj4EDdYT6zVD2H9aZw/view?usp=sharing

1961:Efecto de la castracion y de la hormonoterapia sustitutiva sobre la funcion tiroidea

 https://drive.google.com/file/d/1E8c6YeSXw615copnOKTr6fm_uOgjDeVB/view?usp=sharing

 

Mail: fisiopato2@fmed.uba.ar

El Laboratorio de Patología y Nefrología Experimental está abocado al estudio de la
fisiopatología renal, específicamente, comprender los mecanismos asociados a la evolución de
la injuria renal aguda a la cronicidad y la detección precoz de la lesión renal.
Líneas de trabajo:

  • 1. Estudios en animales

Síndrome Urémico Hemolítico
a. Estudio de evolución a la cronicidad 
b. Rol del podocito en la génesis de la proteinuria
Diabetes tipo 1
Fisiopatología del manejo renal de agua, glucosa y proteínas en el túbulo proximal

  • 2. Estudios en Pacientes

Diagnóstico precoz de falla renal a través de la detección de podocituria
a. Pacientes con nefropatías proteinúricas (Hospital Gutiérrez y Británico)
b. Pacientes con Síndrome Urémico Hemolítico (Hospital Posadas)
c. Pacientes post trasplante renal (Clínica Favaloro)
       

           Integrantes:

  • Elsa Zotta. Dra. en Ciencias Fisiológicas. Médica Patóloga y Legista. Profesora Adjunta
  • Federico Ochoa. Dr. en Ciencias Fisiológicas. Medico Nefrólogo
  • Cristian Costales Collaguazo. Tesista de Doctorado. Medico Nefrólogo
  • Rocío Fernández Peikert. Tesista de Doctorado. Master’s in biomedical sciences (UBA-Friburgo, Alemania). Medica

          Pasantes:

  • Bruno Carabajal, Ayudante de segunda, UA2.
  • Rocio Duete, Ayudante de segunda, UA2.
  • Francisco Martella, Ayudante de segunda, UA2.
  • Mercedes Paciaroni, Ayudante de segunda, UA2.
  • Agustina Tanca, Ayudante de segunda, UA2.

          Colaboradores:

  • Dr. Nestor Lago. Profesor Titular de Patología, Facultad de Medicina, UBA. Director delCentro de Patología Experimental y Aplicada
  • Dr. Marcela Fortunato. Servicio de Nefrología. Favaloro
  • Dr. Miguel Liern, Servicio de Nefrología. Hospital Gutierrez

         Ex integrantes:

  • Dra. Bioq y Farm. Abril Seyahian. Doctorado
  • Méd. Gisela Oltra. Beca estímulo
  • Bioq. Iaria Aldana. Beca Estímulo
  • Master Méd. Santiago Melendi. Beca Peruilh
  • Med. Fernando Chiquilito. Pasante estudiante
  • Bioq. Azul Díaz. Pasante estudiante
  • Méd..  Mariano Pire. Pasante estudiante
  • Méd.. Mora  Galli. Pasante estudiante

 

TRABAJOS REALIZADOS:

TRABAJOS REALIZADOS POR LA DRA ELSA ZOTTA:

https://pubmed.ncbi.nlm.nih.gov/?term=zotta+e

TRABAJOS REALIZADOS POR EL DR FEDERICO OCHOA

https://pubmed.ncbi.nlm.nih.gov/?term=ochoa+f+argentina

 

TRABAJOS REALIZADOS: 

FABRY EN CHICOS: https://drive.google.com/file/d/1Z8EleZHQZ63zMjlNJlHWdtEAi1bbS8wG/view?usp=sharing

FABRY: https://drive.google.com/file/d/17ZCT-AqyKJocgoX_RQUptJn0FKbNxG-_/view?usp=sharing

MICROALBUMINURIA: https://drive.google.com/file/d/1XEl5nTZJRCRupGQnYEOxTlUGTmeeR55/viewusp=sharing

MODELO DE SUH: https://drive.google.com/file/d/1isKKFoMfc4N1A9sdbbPr6c8PXZ4VgZ6Z/view?usp=sharing

PODOCALIXINA: https://drive.google.com/file/d/1qTLZKJcD7H9OsrrCUwBW5l0Luolv5RSR/view?usp=sharing

PODOCITURIA: https://drive.google.com/file/d/1kacnxtMao-jhKqOZJUa208kbwHD1sflH/view?usp=sharing

PODOCITURIA CASE REPORT: https://drive.google.com/file/d/1C9sKUXBInMZuqikK8zQ7gib_ZmVXGwtO/view?usp=sharing

SUBTILASA SISTEMICA: https://drive.google.com/file/d/1sEVG385Bw0TNFu6vQxs1sn1tcm9_UCVP/view?usp=sharing

SUH ATIPICO:https://drive.google.com/file/d/1b7VrCf-b-yqrDAizq4sFAtRqK-Uy_yc9/view?usp=sharing

SUH SUBTILASA EN COLON: https://drive.google.com/file/d/1D9Kb1AQ__rFtBs2N6m-oYSxIlIqSxgei/view?usp=sharing

TGF EN BETA: https://drive.google.com/file/d/1NfP7jDB1vdnKnOjbBosRG8SMHKqcWWBt/view?usp=sharing

TRANSPORTE DE UREA: https://drive.google.com/file/d/1UnELjjivnCG0tgDwB7fTHeuCJD4vB16b/view?usp=sharing

UREA Y ADAPTACION: https://drive.google.com/file/d/1ZAjvF_x6fmwzbcm-B9MJI3R1vl_x7Bhz/view?usp=sharing

UT A2: https://drive.google.com/file/d/1HV0tUSevNOWYHk1QQ0S1W-T6rBQW2lH4/view?usp=sharing

TRABAJOS REALIZADOS:

 

 

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